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    1878-69-9

    Catalog No. EBD6165

    CAS 1878-69-9

    Name 2-(3-Iodophenyl)acetic acid

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    Basic Information

    Synonyms: 3-Iodophenylaceticacid rarechemalbo0414 m-iodophenylaceticacid m-iodobenzeneaceticacid 2-(3-Iodophenyl)aceticacid

    Molecular Formula: C8H7IO2

    Molecular Weight: 262.04

    MDL Number: MFCD00046548

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    2-(3-Iodophenyl)acetic acid is an organic compound featuring a phenyl ring substituted with an iodine atom at the meta position and an acetic acid moiety. This structure combines a reactive aryl iodide, suitable for cross-coupling reactions (e.g., Suzuki, Sonogashira), with a carboxylic acid group, enabling further derivatization. Its primary application is as a versatile building block in medicinal chemistry and pharmaceutical research. The compound is frequently employed in the synthesis of small-molecule drug candidates, particularly as a key intermediate for constructing non-steroidal anti-inflammatory drugs (NSAIDs), kinase inhibitors, and other bioactive molecules targeting the central nervous system or oncology pathways. The iodine atom serves as a convenient handle for late-stage functionalization. Additionally, it functions as a general synthetic building block in organic chemistry. The compound is used to introduce the 3-iodophenylacetic acid motif into more complex structures, serving as a precursor for radiolabeled compounds or as a starting material for developing novel ligands and materials. Standard safety precautions for handling halogenated aromatic acids should be observed.
    Physical Properties

    Melting Point: 127-131 °C(lit.)

    Boiling Point: 347.2°Cat760mmHg

    Flash Point: 163.8°C

    Density: 1.885g/cm3

    mg g kg ml l t