2-(4-Chlorophenyl)ethanol, CAS No. 1875-88-3

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1875-88-3

Catalog No. EBD24357

CAS 1875-88-3

Name 2-(4-Chlorophenyl)ethanol

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Basic Information

Synonyms: 4-chlorobenzeneethanol Benzeneethanol,4-chloro- p-chlorophenethylalcohol P-CHLOROPHENYLETHANOL 2-(4-CHLOROPHENYL)ETHAN-1-OL 2-(P-CHLOROPHENYL)ETHANOL 4-Chlorophenylethanol 4-Chlorophenylaceticalcohol 4-chlorophenethylalcohol 2-(4-Chlorophenyl)ethanol p-chlorophenylethylalcohol 2-(4-chlorophenyl)-1-ethanol phenethylalcohol,p-chloro-(6ci,7ci,8ci)

Molecular Formula: C8H9ClO

Molecular Weight: 156.61

MDL Number: MFCD00002899

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

4-Chlorophenethyl alcohol is an organic compound featuring a benzene ring substituted with a chlorine atom at the para position and an ethanol side chain. It is a white to off-white crystalline solid with a molecular formula of C8H9ClO. This compound serves as a versatile and important building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). For instance, it is a crucial precursor in the production of the antidepressant and anti-anxiety drug, paroxetine, and its derivatives. The reactive hydroxyl and aromatic chlorine groups allow for further functionalization, making it a valuable synthon for constructing more complex molecular architectures. Beyond its pharmaceutical applications, 4-chlorophenethyl alcohol is also utilized in the synthesis of liquid crystals and other fine chemicals. It requires careful handling as it may cause skin and eye irritation.

Physical Properties

Boiling Point: 110 °C/0.5 mmHg(lit.)

Flash Point: >113 °C

Density: 1.157 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.548(lit.)

Analytical Data

Appearance: clear colorless liquid