Diphenylacetyl chloride, CAS No. 1871-76-7

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1871-76-7

Catalog No. EBD16154

CAS 1871-76-7

Name Diphenylacetyl chloride

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Basic Information

Synonyms: 3,3'-(3,3'-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)-bis(2,5-diphenyl-2H-tetrazolium)dichloride Diphenylacetylchloride α-phenylbenzeneacetylchloride 2,2-diphenylacetylchloride acetylchloride,diphenyl- alpha,alpha-diphenylacetylchloride benzeneacetylchloride,alpha-phenyl- diphenylaceticacidchloride a,a-diphenylacetylchloride a-phenylbenzeneacetylchloride acetylchloride,diphenyl-(6ci,7ci,8ci) alpha-Phenylbenzeneacetylchloride

Molecular Formula: C14H11ClO

Molecular Weight: 230.69

MDL Number: MFCD00013655

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

Diphenylacetyl chloride is an organic compound with the formula (C6H5)2CHCOCl. It is a reactive acid chloride derivative of diphenylacetic acid, typically appearing as a colorless to pale yellow liquid or low-melting solid. It is moisture-sensitive and reacts readily with nucleophiles such as water, alcohols, and amines. Its primary role is as a versatile acylating agent and synthetic building block in organic chemistry. It is commonly used to introduce the diphenylacetyl group into target molecules, facilitating the synthesis of amides, esters, and ketones. This functionality makes it valuable in the preparation of various pharmaceutical intermediates, particularly in the synthesis of compounds with potential biological activity, such as certain anticholinergic agents and other pharmacologically relevant structures. Due to its high reactivity, it must be handled under anhydrous conditions, typically using inert atmospheres. It is a lachrymator and corrosive substance, requiring appropriate personal protective equipment. Its main industrial and research significance lies in its utility as a specialized reagent for constructing complex organic molecules rather than in a direct, standalone end-use application.

Physical Properties

Melting Point: 49-53 °C(lit.)

Boiling Point: 175-176 °C/17 mmHg(lit.)

Flash Point: 113 °C

Density: 1.185 g/cm3

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3261

Analytical Data

Appearance: slightly yellow crystalline powder