n6-methyladenosine, CAS No. 1867-73-8

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1867-73-8

Catalog No. EBD224883

CAS 1867-73-8

Name n6-methyladenosine

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Basic Information

Synonyms: 6-methylaminopurine9-ribofuranoside (2r,3s,4r,5r)-2-(hydroxymethyl)-5-(6-methylaminopurin-9-yl)oxolane-3,4-diol n-methyladenosine nsc-29409 6-methylaminopurined-riboside 6-methylaminopurineribonucleoside 6-methylaminopurinosine adenosine,n-methyl- n6-methyladenosine 6-methylaminopurineriboside N(6)-methyladenosine 6-N-Methyladenoside N-methyl-9-pentofuranosyl-9H-purin-6-amine N-methyl-9-alpha-L-ribofuranosyl-9H-purin-6-amine

Molecular Formula: C11H15N5O4

Molecular Weight: 281.27

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Targeted Protein Degradation Tools > Other Targeted Protein Degradation Tools

Product Description:

N6-Methyladenosine hydrochloride (m6A hydrochloride, CAS 1867-73-8) is a chemically modified nucleoside derivative where a methyl group is attached to the nitrogen at the 6th position of the adenine base. It is commonly supplied as a stable hydrochloride salt, which enhances its solubility and handling properties in aqueous and biological buffers. This compound is of paramount importance in the field of epitranscriptomics and RNA biology. N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic messenger RNA (mRNA) and plays a critical regulatory role in RNA metabolism, including splicing, export, stability, and translation. As a research reagent, m6A hydrochloride is used as a standard for mass spectrometry, as a substrate for studying methyltransferases ("writers") and demethylases ("erasers"), and for investigating the function of m6A-binding proteins ("readers"). Its relevance extends to drug discovery, particularly in the development of probes and tools for targeted protein degradation strategies aimed at m6A-regulating proteins. Beyond fundamental research, m6A dysregulation is implicated in various diseases, including cancers and neurological disorders, making this compound a key molecule for diagnostic assay development and therapeutic target validation.

Physical Properties

Boiling Point: 649.1 °C at 760 mmHg

Flash Point: 346.3 °C

Density: 1.85 g/cm3