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    186498-02-2

    Catalog No. EBD5171

    CAS 186498-02-2

    Name 4-Morpholinophenylboronic acid

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    Basic Information

    Synonyms: 4-(MORPHOLINO)PHENYLBORONICACID 4-(MORPHOLIN-4-YL)BENZENEBORONICACID 4-MORPHOLIN-4-YLPHENYLBORONICACID AKOSBRN-0239 4-(N-MORPHOLINO)-BENZENEBORONICACID [4-(4-Morpholinyl)phenyl]boronicacid 4-Morpholinophenylboronicacid 24-(morpholino)phenylboronicacid 4-(morpholino)phenylboronicacid,97%

    Molecular Formula: C10H14BNO3

    Molecular Weight: 207.03

    MDL Number: MFCD03095169

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    4-Morpholinophenylboronic acid is an organoboron compound featuring a phenylboronic acid group substituted at the para position with a morpholine ring. It is a white to off-white crystalline powder with a molecular formula of C10H14BNO3. This compound is a versatile synthetic building block, primarily valued for its role in Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing biaryl and heterobiaryl systems. Its primary application is in pharmaceutical research and development as a key intermediate. The morpholine moiety is a privileged structure in medicinal chemistry, often incorporated to modulate solubility, bioavailability, and target binding. Consequently, this boronic acid is frequently used in the synthesis of potential drug candidates, particularly in constructing complex molecules for biological screening. It serves as a crucial precursor in the synthesis of various heterocyclic compounds and functionalized aromatics. While its main utility is in medicinal chemistry, its fundamental role as a coupling partner also makes it relevant in materials science for constructing conjugated organic frameworks. Standard safety precautions for handling boronic acids and organic solids should be observed, including the use of personal protective equipment to avoid inhalation or contact.
    Physical Properties

    Melting Point: 126 °C

    Boiling Point: 425.9 °C at 760 mmHg

    Flash Point: 211.377 °C

    Density: 1.243 g/cm3

    mg g kg ml l t