2,6-Bis[(4R)-4-(1,1-dimethylethyl)-4,5-dihydro-2-oxazolyl]pyridine is a chiral bis(oxazoline) ligand, commonly abbreviated as (R)-t-Bu-PyBox. It features a central pyridine ring symmetrically substituted at the 2- and 6-positions with two chiral 4-tert-butyl-4,5-dihydrooxazole (oxazoline) rings. This compound is a solid at room temperature. This ligand is a prominent member of the PyBox family, widely used in asymmetric catalysis. It readily coordinates with various transition metals (e.g., copper, zinc, palladium, iridium) to form highly effective chiral Lewis acid catalysts. These metal-ligand complexes are extensively employed in a range of enantioselective transformations, including cyclopropanation, Diels-Alder reactions, aldol reactions, and various carbon-heteroatom bond-forming reactions. Its rigid C2-symmetric structure and the bulky tert-butyl groups are crucial for inducing high enantioselectivity. The (R)-t-Bu-PyBox ligand is a fundamental tool in academic and industrial research focused on asymmetric synthesis. It is commercially available as a high-purity reagent for constructing chiral centers in complex organic molecules, particularly in the synthesis of pharmaceuticals and fine chemicals.