Flucloxacillin sodium, CAS No. 1847-24-1

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1847-24-1

Catalog No. EBD54933

CAS 1847-24-1

Name Flucloxacillin sodium

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Basic Information

Synonyms: (2s-(2-alpha,5-alpha,6-beta))-al 3-dimethyl-7-oxo-henyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-monosodiums 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((3-(2-chloro-6-fluorop 5-methyl-3-(2-chloro-6-fluorophenyl)-4-isoxazolylpenicillinsodium floxacillinsodium floxapensodium flucloxacillinsodiumsalt flucloxacillinsodium 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,monosodiumsalt,(2S,5R,6R)- FloxacillinNasalt MFI-PC Monosodiumflucloxacillin NSC277175 Sodiumflucloxacillin Stafopensodiumsalt StaphylexSodiumsalt 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,monosodiumsalt,(2S-(2-alpha,5-alpha,6-beta))- Sodium(2S-(2alpha,5alpha,6beta))-6-(((3-(2-

Molecular Formula: C19H16ClFN3NaO5S

Molecular Weight: 475.85

MDL Number: MFCD01682108

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Flucloxacillin sodium is a semisynthetic, narrow-spectrum beta-lactam antibiotic belonging to the penicillin class. It is the sodium salt of flucloxacillin, characterized by its isoxazolyl side chain which confers resistance to degradation by bacterial beta-lactamase enzymes, particularly those produced by *Staphylococcus aureus*. Its primary and most significant application is as an active pharmaceutical ingredient (API) for the treatment of bacterial infections caused by susceptible Gram-positive organisms. It is specifically indicated for infections due to beta-lactamase-producing staphylococci, including skin and soft tissue infections, osteomyelitis, and endocarditis. Flucloxacillin is also a key agent in the treatment of neurosyphilis, often used in combination with other antibiotics, which justifies its secondary classification under nervous system drugs. Administration is typically via oral or intravenous routes. A notable safety concern associated with flucloxacillin is the risk of drug-induced liver injury (cholestatic hepatitis), which, although rare, can be severe. It remains a critical antibiotic in regions with a high prevalence of penicillinase-producing staphylococci.

Physical Properties

Melting Point: 176-178 °C

Boiling Point: 677.3 °C at 760 mmHg

Flash Point: 363.4 °C

Storage: 2-8°C

Analytical Data

Appearance: White solid