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    18368-64-4

    Catalog No. EBD34013

    CAS 18368-64-4

    Name 2-Chloro-5-methylpyridine

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    Basic Information

    Synonyms: 6-Chloro-3-picoline 2-Chloro-5-picoline 2-Chloro-5-methylpyridine

    Molecular Formula: C6H6ClN

    Molecular Weight: 127.57

    MDL Number: MFCD00792460

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Agrochemicals > Pesticide Chemistry > Pesticide Intermediates

    Product Description:
    2-Chloro-5-methylpyridine is a heterocyclic organic compound featuring a pyridine ring substituted with a chlorine atom at the 2-position and a methyl group at the 5-position. It is a key building block in the synthesis of various pharmaceuticals and agrochemicals. In the pharmaceutical sector, it serves as a crucial intermediate for the production of active pharmaceutical ingredients (APIs), particularly in the development of proton pump inhibitors (e.g., lansoprazole) and other therapeutic agents. In agrochemistry, it is widely utilized as an intermediate for manufacturing insecticides and herbicides, such as neonicotinoid pesticides, due to its ability to introduce specific biological activity through further functionalization. The compound is typically a colorless to pale yellow liquid or low-melting solid, stable under normal conditions, and handled with standard safety precautions due to its irritant properties. Its versatility in cross-coupling and nucleophilic substitution reactions makes it a valuable synthetic intermediate across multiple industries.
    Physical Properties

    Boiling Point: 97 °C/30 mmHg(lit.)

    Flash Point: 195 °F

    Density: 1.169 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.53(lit.)

    Analytical Data

    Appearance: clear light yellow to straw-yellow liquid

    mg g kg ml l t