N-Boc-4-(Fmoc-amino)piperidine-4-carboxylic acid, CAS No. 183673-66-7

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183673-66-7

Catalog No. EBD47133

CAS 183673-66-7

Name N-Boc-4-(Fmoc-amino)piperidine-4-carboxylic acid

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Basic Information

Synonyms: N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylicacid N-(9-Fluorenylmethoxycarbonyl)-amino-(4-N-(tert-butoxycarbonyl)-piperidinyl)carboxylicacid 1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}piperidine-4-carboxylicacid 1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}piperidine-4-carboxylate 1-(N-Boc)-4-(Fmoc-amino)-piperidine-4-carboxylicacid 1-N-Boc-4-N-Fmoc-amino-4-carboxylic-piperidine 1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid 4-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Piperidine-1,4-DicarboxylicAcidMono-Tert-ButylEster N-Boc-4-(Fmoc-amino)piperidine-4-carboxylicacid 1-(tert-butoxycarbonyl)-4-([(9h-fluoren-9-ylmethoxy)carbonyl]amino)piperidine-4-carboxylicacid 1-(tert-butoxycarbonyl)-4-fluorenylmethoxycarbonylaminopiperidine-4-carboxylicacid 1-n-boc-4-n-fmoc-aminopiperidine-4-carboxylicacid 1-boc-4-fmoc-pip-oh 1-boc-4-(fmoc-amino)-piperidine-4-carboxylicacid 1-boc-piperidine-4-fmoc-amin

Molecular Formula: C26H30N2O6

Molecular Weight: 466.53

MDL Number: MFCD01318741

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-4-(Fmoc-amino)piperidine-4-carboxylic acid is a protected heterocyclic amino acid derivative. It features a piperidine ring core that is simultaneously functionalized with a tert-butoxycarbonyl (Boc) protecting group on the nitrogen and a 9-fluorenylmethoxycarbonyl (Fmoc)-protected amino group and a carboxylic acid group at the 4-position. This bifunctional structure makes it a versatile building block. This compound is primarily employed as a key intermediate in solid-phase peptide synthesis (SPPS) and the synthesis of peptidomimetics. The orthogonal protection strategy (Boc and Fmoc) allows for selective deprotection and sequential chain elongation, making it valuable for constructing complex peptide sequences and constrained scaffolds that incorporate the piperidine moiety. The piperidine ring is a common pharmacophore found in numerous bioactive molecules. Its applications extend to medicinal chemistry for the development of drug candidates targeting various diseases, including central nervous system disorders and infectious diseases, where the rigid, basic piperidine structure can influence pharmacokinetic properties and receptor binding.

Physical Properties

Boiling Point: 657.8 °C at 760 mmHg

Flash Point: 351.6 °C

Density: 1.31 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white to cream crystalline powder or chunks