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    1821428-35-6

    Catalog No. EBD4029069

    CAS 1821428-35-6

    Name 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-2H-Imidazo[4,5-c]quinolin-2-one

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    Basic Information

    Synonyms: AZD-0156 AZD0156

    Molecular Formula: C26H31N5O3

    Molecular Weight: 461.56

    Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Targeted Protein Degradation Tools > Ligand-Linker Conjugates

    Product Description:
    8-[6-[3-(Dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-2H-imidazo[4,5-c]quinolin-2-one is a heterocyclic compound featuring a complex imidazo[4,5-c]quinolin-2-one core linked to a pyridine moiety via a propoxy chain. This specific molecular architecture is characteristic of a PROTAC (Proteolysis Targeting Chimera) molecule. This compound is a key intermediate or a final PROTAC degrader molecule designed to target specific proteins for degradation. It functions as a bifunctional chimera, where one end (the imidazo[4,5-c]quinolin-2-one core) is a ligand designed to bind a target protein of interest (POI), and the other end (the pyridine with a dimethylaminopropoxy linker) is connected to a ligand for an E3 ubiquitin ligase. This proximity induces ubiquitination and subsequent proteasomal degradation of the POI, offering a novel therapeutic strategy beyond traditional inhibition. Research and development efforts involving this compound are primarily focused in the field of oncology, targeting proteins implicated in cancer progression. Its synthesis and application are highly specialized within medicinal chemistry and chemical biology for the development of next-generation targeted cancer therapies.
    Physical Properties
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