Boc-D-2-Indanylglycine is a non-proteinogenic, unnatural amino acid derivative. Its structure features a D-configuration indane ring system attached to the glycine backbone, with the amine group protected by a tert-butyloxycarbonyl (Boc) group. This specific stereochemistry and protecting group make it a valuable chiral building block. This compound is primarily employed in the field of peptide chemistry and medicinal chemistry. It serves as a key synthetic intermediate for the construction of peptides and peptidomimetics. The incorporation of the rigid, hydrophobic indane moiety can significantly alter the conformational, pharmacokinetic, and binding properties of the resulting peptide, which is crucial for drug discovery efforts targeting various diseases. It is particularly relevant in the synthesis of protease inhibitors and other bioactive peptide analogs. The Boc protecting group is acid-labile, allowing for selective deprotection under mild acidic conditions without affecting other sensitive functional groups, which is standard in solid-phase peptide synthesis (SPPS) and solution-phase strategies. Its use facilitates the stepwise assembly of complex peptide sequences.