N-Acetyl-D-galactosamine, CAS No. 1811-31-0

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1811-31-0

Catalog No. EBD3313757

CAS 1811-31-0

Name N-Acetyl-D-galactosamine

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Basic Information

Synonyms: N-Acetyl-D-galactosamine n-acetylgalactosamine n-acetylchondrosamine n-acetyl-alpha-d-galactosamine d-galnac galnac 2-acetamido-2-deoxy-d-galactose 2-acetamido-2-deoxy-alpha-d-galactose acetyl-b-d-galactosamine,n- N-acetyl-β-D-galactosamine N-Acetyl-D-glactosamine 2-Acetamido-2-deoxyD-galactose 2-Acetamido-2-deoxy-D-galactopyranose 2-(acetylamino)-2-deoxy-alpha-D-galactopyranose 2-(acetylamino)-2-deoxy-D-galactose (2E)-oct-2-enedioicacid N-[(1R,2S,3S,4R)-1-formyl-2,3,4,5-tetrahydroxy-pentyl]acetamide

Molecular Formula: C8H15NO6

Molecular Weight: 221.21

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Excipients > Novel and Functional Excipients

Product Description:

N-Acetyl-D-galactosamine (GalNAc) is a monosaccharide derivative, specifically the N-acetylated form of the amino sugar D-galactosamine. It is a key structural component of glycoproteins, glycolipids, and proteoglycans, playing a crucial role in cell-cell recognition, signaling, and immune responses. Its primary application in the pharmaceutical industry is as a targeting ligand for liver-specific drug delivery. Conjugating therapeutic agents (like antisense oligonucleotides or siRNA) to triantennary GalNAc clusters enables highly efficient uptake into hepatocytes via the asialoglycoprotein receptor (ASGPR), which is abundantly expressed on liver cells. This technology has revolutionized the development of RNA-targeted therapies. Furthermore, GalNAc and its derivatives are used as building blocks for synthesizing complex carbohydrates, glycoconjugates, and as substrates for glycosyltransferase enzymes in biochemical research. As a functional excipient, GalNAc-based conjugates represent a novel class of delivery-enhancing agents. It is also investigated for its role in immunology and as a potential biomarker. The compound is generally considered safe for research and pharmaceutical use when handled under standard laboratory conditions.

Physical Properties

Melting Point: 160-161

Boiling Point: 636.4 °C at 760 mmHg

Flash Point: 338.7 °C

Density: 1.423 g/cm3

Solubility: H2O: 0.1 g/mL, clear, colorless

Storage: 2-8°C

Analytical Data

Appearance: white to off-white crystalline powder