(S)-1-tert-butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate, CAS No. 180854-44-8

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180854-44-8

Catalog No. EBD2597113

CAS 180854-44-8

Name (S)-1-tert-butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate

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Basic Information

Synonyms: (2S)-4-oxo-1,2-Piperidinedicarboxylicacid1-(tert-butyl)2-ethylester (S)-1-tert-butyl2-ethyl4-oxopiperidine-1,2-dicarboxylate (2S)-N-tert-butoxycarbonyl-4-oxopiperidine-2-carboxylicacidethylester ETHYL(S)-1-BOC-4-OXOPIPERIDINE-2-CARBOXYLATE 1,2-Piperidinedicarboxylicacid,4-oxo-,1-(1,1-diMethylethyl)2-ethylester,(2S)- (S)-1-Boc-4-oxo-piperidine-2-carboxylicacidmethyleste (S)-1-BOC-4-OXO-PIPERIDINE-2-CARBOXYLICACIDMETHYLESTER Ethyl(S)-N-(tert-butoxycarbonyl)-4-oxo-2-pipecolate PBN20120647 (S)-1-Boc-4-oxo-piperidine-2-carboxylicacidmethylesteree Ethyl(S)-1-Boc-4-oxopiperidine-2-carboxylate

Molecular Formula: C13H21NO5

Molecular Weight: 271.31

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-tert-butyl 2-ethyl 4-oxopiperidine-1,2-dicarboxylate is a chiral piperidine derivative featuring a Boc-protected amine and an ethyl ester group at the 2-position, along with a ketone at the 4-position. This specific stereochemistry ((S)-configuration) and functional group arrangement make it a valuable non-racemic building block. This compound is primarily employed as a key chiral intermediate in pharmaceutical synthesis. Its structure serves as a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. The presence of orthogonal protecting groups (Boc and ethyl ester) and a reactive ketone allows for selective modifications, enabling efficient synthesis of target molecules with defined stereocenters. While its primary application is in medicinal chemistry as a pharmaceutical intermediate, its well-defined structure and functional handles also position it as a specialized organic synthesis building block for research and development in asymmetric synthesis.

Physical Properties

Flash Point: >110 °C

Density: 1.079 g/mL at 25 °C

Refractivity: n20/D 1.464