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    179899-07-1

    Catalog No. EBD3060869

    CAS 179899-07-1

    Name 4-FLUORO-2-METHOXYPHENYLBORONIC ACID

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    Basic Information

    Synonyms: AKOSBRN-0234 5-FLUOROANISOLE-2-BORONICACID 4-FLUORO-2-METHOXYPHENYLBORONI 2-METHOXY-4-FLUOROPHENYLBORONICACID 4-FLUORO-2-METHOXYPHENYLBORONICACID 4-FLUORO-2-METHOXYBENZENEBORONICACID (4-Fluoro-2-methoxyphenyl)boronicacid

    Molecular Formula: C7H8BFO3

    Molecular Weight: 169.95

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    4-Fluoro-2-methoxyphenylboronic acid is an organoboron compound featuring a boronic acid functional group attached to a substituted phenyl ring containing fluorine and methoxy substituents. It is a white to off-white crystalline powder commonly used as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. This compound serves as a key synthetic intermediate in the preparation of various pharmaceuticals and bioactive molecules. Its structural motif is found in the synthesis of compounds with potential biological activity, including kinase inhibitors and other small-molecule drug candidates. The presence of both electron-donating (methoxy) and electron-withdrawing (fluoro) groups makes it a valuable substrate for constructing complex aromatic systems with specific electronic properties. As a boronic acid derivative, it requires careful handling and storage under inert conditions to prevent protodeboronation or oxidation. It is typically stored at low temperatures (e.g., 2-8°C) and is commercially available from suppliers of fine chemicals and advanced synthetic intermediates for research and development purposes.
    Physical Properties

    Melting Point: 131-136 °C(lit.)

    Boiling Point: 294.761 °C at 760 mmHg

    Flash Point: 132.067 °C

    Density: 1.265 g/cm3

    mg g kg ml l t