(R)-1-hydroxy-1-phenylacetone, CAS No. 1798-60-3

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1798-60-3

Catalog No. EBD3315232

CAS 1798-60-3

Name (R)-1-hydroxy-1-phenylacetone

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Basic Information

Synonyms: (R)-1-hydroxy-1-phenylacetone (r)-1-hydroxy-1-phenylaceton (1r)-1-hydroxy-1-phenyl-2-propanone (1r)-1-phenyl-1-hydroxy-2-propanone (r)-1-hydroxy-1-phenyl-2-propanone (r)-1-phenyl-1-hydroxy-2-propanone (r)-α-acetylbenzenemethanol [r,(-)]-1-hydroxy-1-phenyl-2-propanone 1-hydroxy-1-phenylpropan-2-one (1R)-1-hydroxy-1-phenylpropan-2-one

Molecular Formula: C9H10O2

Molecular Weight: 150.17

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Other Biochemicals and Life Science Reagents

Product Description:

L-Phenylacetylcarbinol (L-PAC), also known as (R)-1-hydroxy-1-phenylpropan-2-one, is a chiral α-hydroxy ketone with the CAS number 1798-60-3. It is a key intermediate in the synthesis of L-ephedrine and pseudoephedrine, which are important pharmaceutical compounds used as decongestants and bronchodilators. Its primary industrial significance lies in its role as a precursor in the biosynthesis of ephedrine alkaloids. L-PAC is typically produced via a biotransformation process using yeast (e.g., *Saccharomyces cerevisiae* or *Candida utilis*), where pyruvate decarboxylase catalyzes the condensation of benzaldehyde with pyruvate. This biocatalytic route offers an efficient and stereoselective alternative to traditional chemical synthesis. Due to its chiral nature and specific application as a building block for active pharmaceutical ingredients (APIs), L-PAC is classified as a pharmaceutical intermediate. Its production and use are central to the manufacture of several adrenergic drugs.

Physical Properties

Boiling Point: 253.343 °C at 760 mmHg

Flash Point: 104.584 °C

Density: 1.12 g/cm3