3-Tolylboronic acid, CAS No. 17933-03-8

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

17933-03-8

Catalog No. EBD435299

CAS 17933-03-8

Name 3-Tolylboronic acid

Get Quote

Basic Information

Synonyms: 3-Tolylboronicacid 3-methylbenzeneboronicacid (3-methylphenyl)boronicacid 3-Methylphenylboricacid 3-Methylphenylboronicacid: m-Tolylboronicacid

Molecular Formula: C7H9BO2

Molecular Weight: 135.96

MDL Number: MFCD00040198

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

3-Methylphenylboronic acid is an organoboron compound characterized by a phenyl ring substituted with a boronic acid group (-B(OH)₂) at the meta position relative to a methyl group. It is a white to off-white crystalline powder that is sensitive to air and moisture, often requiring storage under inert conditions. This compound serves as a versatile and crucial building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. In this palladium-catalyzed process, it acts as an arylboron reagent to form new carbon-carbon bonds, enabling the efficient construction of biaryl and other complex aromatic structures. This methodology is fundamental in the synthesis of numerous pharmaceuticals, agrochemicals, and advanced materials. Its primary application is in medicinal chemistry as a key intermediate for constructing drug candidates. The meta-tolyl moiety introduced by this reagent is found in various bioactive molecules. Consequently, it is widely used in research and development for synthesizing potential active pharmaceutical ingredients (APIs) and their intermediates.

Physical Properties

Melting Point: 160-162 °C(lit.)

Boiling Point: 290.4 °C at 760 mmHg

Flash Point: 129.4 °C

Density: 1.1 g/cm3

Storage: 0-6°C

Analytical Data

Appearance: off-white crystal