Myricitrin, also known as myricetin 3-O-rhamnoside, is a naturally occurring flavonoid glycoside. It is primarily isolated from plants such as *Myrica rubra* (Chinese bayberry), *Ginkgo biloba*, and various other medicinal herbs. The compound consists of the flavonol aglycone myricetin linked to a rhamnose sugar moiety. Myricitrin exhibits a broad spectrum of pharmacological activities, underpinning its primary applications in pharmaceutical research and nutraceuticals. It possesses potent antioxidant, anti-inflammatory, and anti-diabetic properties. Studies highlight its neuroprotective effects, hepatoprotective activity, and potential in managing cardiovascular diseases. Its mechanism often involves scavenging free radicals, modulating key signaling pathways (e.g., NF-κB, MAPK), and inhibiting enzymes like α-glucosidase. Due to its bioactivity and natural origin, it is also explored as a functional ingredient in cosmetic formulations for its skin-protective and anti-aging effects. The compound is commercially available as a high-purity standard for research, including in vitro and in vivo studies. Its safety profile is generally favorable, but like many bioactive compounds, efficacy and toxicity are dose-dependent. Ongoing research continues to investigate its therapeutic potential and delivery systems for enhanced bioavailability.