Propitocaine hydrochloride, CAS No. 1786-81-8

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1786-81-8

Catalog No. EBD2408

CAS 1786-81-8

Name Propitocaine hydrochloride

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Basic Information

Synonyms: alpha-propylamino-2'-methylpropionanilidehydrochloride Citanest N-(2-Methylphenyl)-2-(propylamino)-propanamidehydrochloride N-(a-propylaminopropionyl)-o-toluidinehydrochloride Prilocainehydrochloride Xylonest N-(2-methylphenyl)-N~2~-propylalaninamidehydrochloride(1:1) PropitocaineHCL PrilocaineHCl 2-(Propylamino)-o-propionotoluididehydrochloride Propitocainehydrochloride

Molecular Formula: C13H21ClN2O

Molecular Weight: 256.77

MDL Number: MFCD00079279

Categories: Medicinal Chemistry > APIs and Their Salts > Anesthetics and Analgesics Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Prilocaine hydrochloride is a local anesthetic of the amino amide type. It is chemically known as 2-(propylamino)-o-propionotoluidide hydrochloride. The compound is a white, crystalline powder that is freely soluble in water and alcohol. Prilocaine is primarily used as a local anesthetic for infiltration, nerve block, and epidural anesthesia. It is known for its rapid onset of action and moderate duration. A key characteristic of prilocaine is its relatively low systemic toxicity compared to some other amide-type anesthetics, partly due to its rapid metabolism. It is a component of the widely used topical anesthetic cream EMLA (Eutectic Mixture of Local Anesthetics), which combines prilocaine and lidocaine. As an active pharmaceutical ingredient (API), prilocaine hydrochloride is also associated with specific impurities and degradation products that require monitoring during pharmaceutical manufacturing and quality control. Therefore, it and its related compounds serve as important reference standards in analytical laboratories.

Physical Properties

Boiling Point: 361.6 °C at 760 mmHg

Flash Point: 134.3 °C