(2-Amino-5-nitrophenyl)(phenyl)methanone, CAS No. 1775-95-7

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1775-95-7

Catalog No. EBD4522

CAS 1775-95-7

Name (2-Amino-5-nitrophenyl)(phenyl)methanone

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Basic Information

Synonyms: 2-Amino-5-nitrobenzophenone (2-Amino-5-nitrophenyl)phenylmethanone 4-14-00-00246(BeilsteinHandbookReference) BRN0748830 Methanone,(2-amino-5-nitrophenyl)phenyl- (2-amino-5-nitrophenyl)phenyl-methanon 2-amino-5-nitrodiphenylmethone 2-amino-5-nitrodiphenylone 2-benzoyl-4-nitroaniline 5-nitro-2-aminobenzophenone benzophenone,2-amino-5-nitro- (2-Amino-5-nitrophenyl)(phenyl)methanone

Molecular Formula: C13H10N2O3

Molecular Weight: 242.23

MDL Number: MFCD00007364

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Amino-5-nitrobenzophenone is an organic compound featuring a benzophenone core substituted with an amino group at the 2-position and a nitro group at the 5-position. It serves as a versatile and important chemical intermediate in organic synthesis. Its primary and most significant application is in the pharmaceutical industry as a key building block for the synthesis of benzodiazepine drugs. Specifically, it is a crucial precursor in the manufacturing of Nitrazepam, a sedative and hypnotic medication belonging to the nitro-benzodiazepine class. The compound's structure allows for cyclization reactions to form the characteristic diazepine ring system. While its dominant use is as a pharmaceutical intermediate, its structure also makes it a valuable synthetic building block in research chemistry, particularly for constructing molecules containing both amine and nitro functionalities on an aromatic ketone scaffold.

Physical Properties

Melting Point: 166-168 °C(lit.)

Boiling Point: 478.1 °C at 760 mmHg

Flash Point: 242.9 °C

Density: 1.333 g/cm3

Solubility: 3 mg/L (20 C)

Analytical Data

Appearance: yellow solid