Fmoc-3-(3-pyridyl)-L-alanine, CAS No. 175453-07-3

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175453-07-3

Catalog No. EBD2127889

CAS 175453-07-3

Name Fmoc-3-(3-pyridyl)-L-alanine

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Basic Information

Synonyms: (s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-pyridin-3-yl-propionicacid rarechemakml0095 n-alpha-(9-fluorenylmethyloxycarbonyl)-3-(3-pyridyl)-l-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-3-(3-pyridyl)-l-alanine n-(9-fluorenylmethoxycarbonyl)-3-pyridyl-l-alanine n-alpha-fmoc-beta-(3-pyridyl)-l-alanine fmoc-(s)-2-amino-3-(3'-pyridyl)propanoicacid Fmoc-3-(3-pyridyl)-L-alanine Fmoc-L-3-(3-Pyridyl)-alanine (S)-N-FMOC-(3-Pyridyl)alanine Fmoc-L-3-Pyridylalanine

Molecular Formula: C23H20N2O4

Molecular Weight: 388.42

MDL Number: MFCD00144887

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

Fmoc-3-(3-pyridyl)-L-alanine is a non-natural, protected amino acid derivative. Its structure features an L-alanine backbone with a 3-pyridyl substituent at the β-position and an N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is a solid under standard conditions. This amino acid derivative is a specialized building block primarily used in solid-phase peptide synthesis (SPPS) employing the Fmoc strategy. The pyridyl side chain introduces unique properties into the peptide sequence, such as potential metal coordination sites, hydrogen bonding capability, and altered hydrophilicity. It is therefore a critical reagent for constructing peptides with specific structural motifs, for studying protein-protein interactions, or for developing peptide-based drugs and bioactive probes. As a non-proteinogenic amino acid, it is a key component in the toolbox of peptide chemists and medicinal chemistry researchers for exploring structure-activity relationships and creating novel peptide architectures with tailored functions.

Physical Properties

Melting Point: 155.3 °C

Boiling Point: 645.6 °C at 760 mmHg

Flash Point: 344.3 °C

Density: 1.309 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white to off-white crystalline powder