Corynoxine B is a natural indole alkaloid isolated from the traditional Chinese medicinal herb *Uncaria rhynchophylla* (Gou-Teng). It is a stereoisomer of Corynoxine, sharing the same molecular formula (C22H28N2O4) but differing in the configuration at the C-3 and C-20 positions. This compound is a key bioactive constituent of the plant. Extensive pharmacological studies have demonstrated that Corynoxine B possesses significant neuroprotective and neurotrophic activities. It is a well-known autophagy enhancer, promoting the clearance of misfolded proteins like α-synuclein and amyloid-β, which are implicated in neurodegenerative diseases such as Parkinson's and Alzheimer's. Its mechanism involves the activation of the Akt/mTOR pathway and the promotion of autophagosome formation. Due to these properties, it is a valuable reference standard and a promising lead compound for the development of novel therapeutic agents targeting neurodegenerative disorders. As a pure natural product, Corynoxine B serves as a crucial chemical marker for the quality control of *Uncaria* species and related herbal preparations. It is primarily used in biomedical research as a pharmacological tool to study autophagy mechanisms and in drug discovery programs focused on central nervous system diseases.