(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine, CAS No. 171338-27-5

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171338-27-5

Catalog No. EBD22996

CAS 171338-27-5

Name (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine

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Basic Information

Synonyms: (2r,3s)-2-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-morpholine 2-(r)-[1-(r)-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(s)-fluorophenylmorpholine 2-(r)-[1-(r)-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(s)-fluorophenylmorpholine[aprepitant-m2] (2r,3s)-2-[(1r)-1-[3,5-bis(trifluoromethyl]ethoxy]-3-(4-fluorophenyl)morpholine (2r,3s)-2-((r)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine (2r,3s)-2-(1r)-1-3,5-bis(trifluoromethyl)phenyl) morpholine,2-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-,(2r,3s)- morpholine,2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-,[2r-[2a(r*),3a]]- (2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-

Molecular Formula: C20H18F7NO2

Molecular Weight: 437.35

MDL Number: MFCD09952149

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine is a chiral morpholine derivative characterized by a complex stereochemistry with multiple chiral centers. Its structure features a morpholine ring substituted with a 4-fluorophenyl group and an ether linkage to a chiral benzylic alcohol moiety bearing two trifluoromethyl groups. This compound is a high-value, advanced pharmaceutical intermediate. This compound is a key chiral intermediate in the synthesis of Aprepitant, a potent and selective neurokinin-1 (NK1) receptor antagonist. Aprepitant is an antiemetic drug used to prevent nausea and vomiting caused by chemotherapy. The specific stereochemistry of this intermediate is crucial for the biological activity of the final drug substance. Its synthesis and purification are critical steps in the manufacturing process of Aprepitant. The presence of the trifluoromethyl groups enhances the lipophilicity and metabolic stability of the molecule. Due to its role in producing a commercial API, this intermediate is produced under strict quality control standards. It is typically handled in controlled environments for pharmaceutical production and is not a general-purpose laboratory reagent.

Physical Properties

Boiling Point: 387.856 °C at 760 mmHg

Flash Point: 188.369 °C

Density: 1.375 g/cm3