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    171037-01-7

    Catalog No. EBD2215660

    CAS 171037-01-7

    Name (R)-2-Amino-3,3-diphenylpropan-1-ol

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    Basic Information

    Synonyms: (r)-diphenylalaninol (R)-2-Amino-3,3-diphenylpropan-1-ol

    Molecular Formula: C15H17NO

    Molecular Weight: 227.3

    MDL Number: MFCD08063386

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-2-Amino-3,3-diphenylpropan-1-ol is a chiral amino alcohol compound characterized by a central carbon bearing two phenyl groups and a hydroxymethyl group, with the amino group at the chiral center in the (R)-configuration. This structure imparts significant utility as a chiral building block and ligand in asymmetric synthesis. This compound serves as a crucial chiral intermediate in pharmaceutical research and development. Its primary application is in the synthesis of chiral drugs, particularly as a key precursor for (R)-2-amino-1,1-diphenylpropan-1-ol, which is a vital intermediate for the production of (R)-tolterodine. (R)-Tolterodine is the active enantiomer of the widely used antimuscarinic drug tolterodine tartrate, prescribed for the treatment of overactive bladder. The chiral integrity of this intermediate is essential for the efficacy of the final API. Beyond its direct pharmaceutical application, (R)-2-Amino-3,3-diphenylpropan-1-ol is also employed as a chiral ligand or auxiliary in various catalytic asymmetric reactions, leveraging its rigid, bulky diphenylmethyl moiety to induce high enantioselectivity. It is typically handled as a solid and requires storage under inert conditions.
    Physical Properties
    mg g kg ml l t