Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    170902-76-8

    Catalog No. EBD22778

    CAS 170902-76-8

    Name (R)-Amino-(4-fluoro-phenyl)-acetic acid methyl ester

    Get Quote
    Basic Information

    Synonyms: METHYLD-2-(4-FLUOROPHENYL)GLYCINATE Benzeneaceticacid,alpha-amino-4-fluoro-,methylester,(alphaR)- Methyl(2R)-amino(4-fluorophenyl)acetate methyl(2R)-amino(4-fluorophenyl)ethanoate (R)-Amino-(4-fluoro-phenyl)-aceticacidmethylester

    Molecular Formula: C9H10FNO2

    Molecular Weight: 183.18

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Targeted Protein Degradation Tools > Linkers

    Product Description:
    1-(1,3-Benzodioxol-5-yl)-N-hydroxypropan-2-amine is a chemical compound featuring a benzodioxole moiety linked to a hydroxyamine group via a propan-2-amine chain. This structure makes it a versatile building block, particularly valued for its hydroxamic acid precursor functionality. Its primary and most significant application is in medicinal chemistry as a key intermediate for the synthesis of histone deacetylase (HDAC) inhibitors. The hydroxamic acid group, which can be derived from this compound, is a critical pharmacophore known for chelating the zinc ion in the active site of HDAC enzymes. This compound serves as a crucial precursor in the development of anticancer agents, such as certain derivatives of vorinostat (SAHA). Furthermore, the presence of both a reactive amine (or hydroxylamine) and a privileged benzodioxole scaffold makes it a candidate for use in constructing linkers for targeted protein degradation (PROTACs) or other bifunctional molecules. It is primarily supplied for research and development purposes in pharmaceutical synthesis.
    Physical Properties

    Boiling Point: 241.001°C at 760 mmHg

    Flash Point: 99.554°C

    Density: 1.214g/cm3

    mg g kg ml l t