Boc-N-Me-Ala-OH, CAS No. 16948-16-6

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16948-16-6

Catalog No. EBD2198071

CAS 16948-16-6

Name Boc-N-Me-Ala-OH

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Basic Information

Synonyms: Boc-N-Me-Ala-OH boc-N-methyl-L-alanine N-alpha-t-butyloxycabonyl-N-alpha-Methyl-L-alanine N-Boc-N-methyl-L-alanine N-(tert-butoxycarbonyl)-N-methyl-L-alanine Boc-N-Me-Ala-OH[Boc-N-methyl-L-alanine] Boc-MeAla-OH Boc-N-Me-S-Ala-OH Boc-Lys(TFA)

Molecular Formula: C9H17NO4

Molecular Weight: 203.24

MDL Number: MFCD00037242

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Boc-N-Me-Ala-OH is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc)-protected form of N-methyl-L-alanine. It is a white to off-white crystalline powder with a molecular formula of C9H17NO4 and a molecular weight of 203.24 g/mol. This compound is a crucial chiral building block in organic and peptide synthesis. Its primary application is in the field of pharmaceutical chemistry as a key intermediate for the synthesis of modified peptides and peptidomimetics. The N-methylation of the amide bond enhances the metabolic stability, membrane permeability, and bioavailability of the resulting peptides. Therefore, Boc-N-Me-Ala-OH is extensively used in the research and development of therapeutic agents, including protease inhibitors and other bioactive molecules. As a versatile synthon, it is employed in solid-phase peptide synthesis (SPPS) and solution-phase methods. The Boc protecting group can be selectively removed under acidic conditions without affecting other common protecting groups. It is commercially available from major suppliers of fine chemicals and biochemicals for research purposes.

Physical Properties

Melting Point: 88-92 °C

Boiling Point: 296.3 °C at 760 mmHg

Flash Point: 133 °C

Density: 1.111 g/cm3

Storage: Store at RT.