3-Pyridylboronic acid, CAS No. 1692-25-7

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1692-25-7

Catalog No. EBD435812

CAS 1692-25-7

Name 3-Pyridylboronic acid

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Basic Information

Synonyms: rarechemahpb0251 pyridin-3-ylboronicacid pyridin-3-boronicacid pyridin-3-yl-3-boronicacid pyridyl-3-boronicacid pyridine-3-boronicacid akosbrn-0272 3-Pyridylboronicacid Pyridine-3-boronicacidl 3-Pyridineboronicacid (pyridin-3-yl)boronicacid 3-Pyridinylboronicacid

Molecular Formula: C5H6BNO2

Molecular Weight: 122.92

MDL Number: MFCD00674177

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

3-Pyridylboronic acid is an organoboron compound featuring a pyridine ring substituted with a boronic acid group at the 3-position. It appears as a white to off-white crystalline powder and is a fundamental building block in organic synthesis. Its primary application is as a key intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the formation of carbon-carbon bonds to construct complex biaryl structures. This makes it indispensable in the pharmaceutical industry for synthesizing a wide range of drug candidates, particularly those containing pyridine moieties, such as kinase inhibitors and other heterocyclic active pharmaceutical ingredients (APIs). It is also utilized in the development of agrochemicals and functional materials. As a versatile synthetic building block, 3-Pyridylboronic acid is widely employed in medicinal chemistry for fragment-based drug discovery and the rapid generation of chemical libraries. It should be stored under inert atmosphere and kept in a cool, dry place to prevent degradation.

Physical Properties

Melting Point: >300 °C(lit.)

Boiling Point: 308.8 ºC at 760 mmHg

Flash Point: 140.5 ºC

Density: 1.23 g/cm3

Storage: 0-6°C

Analytical Data

Appearance: Light yellow powder