Pyridin-4-ylboronic acid, CAS No. 1692-15-5

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1692-15-5

Catalog No. EBD541232

CAS 1692-15-5

Name Pyridin-4-ylboronic acid

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Basic Information

Synonyms: 4-Pyridylboronic Acid (contains varying amounts of Anhydride) Pyridin-4-ylboronicacid 4-Pyridylboronicacid 4-Pyridineboronicacid 4-pyridylboronicacidhydrochloride PYRIDIN-4-YL-4-BORONICACID PYRIDINE-4-BORONICACIDHYDRATE (pyridin-4-yl)boronicacid pyridyl-4-boronicacid pyridine-4-boronicacid rarechemahpb0240 timtec-bbsbb004280 akosbrn-0273 4-Pyridinylboronicacid

Molecular Formula: C5H6BNO2

Molecular Weight: 122.92

MDL Number: MFCD01074545

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

Pyridin-4-ylboronic acid is an organoboron compound featuring a boronic acid group directly attached to the 4-position of a pyridine ring. It is a white to off-white crystalline solid that is sensitive to air and moisture. As a heterocyclic boronic acid, it serves as a key building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. Its primary application is as a versatile synthetic intermediate in the pharmaceutical and agrochemical industries. The compound enables the formation of carbon-carbon bonds, allowing for the introduction of the 4-pyridyl moiety into complex molecular scaffolds. This makes it invaluable for constructing drug candidates, including kinase inhibitors and other bioactive molecules targeting neurological or inflammatory pathways. It is also used in the development of functional materials and ligands for catalysis. Due to its reactivity, the compound should be stored under inert atmosphere and in a cool, dry place. It is typically used in the presence of a palladium catalyst and a base to facilitate coupling with aryl or vinyl halides. Its role as a fundamental building block in both medicinal chemistry and general synthetic chemistry justifies its classification under both categories.

Physical Properties

Melting Point: >300 °C(lit.)

Boiling Point: 308.782 °C at 760 mmHg

Flash Point: 140.547 °C

Density: 1.23 g/cm3

Storage: −20°C

Analytical Data

Appearance: light orange granular powder