5-(Trifluoromethoxy)-1H-indole-2,3-dione, CAS No. 169037-23-4

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169037-23-4

Catalog No. EBD41504

CAS 169037-23-4

Name 5-(Trifluoromethoxy)-1H-indole-2,3-dione

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Basic Information

Synonyms: buttpark347-90 5-(trifluoromethoxy)isatin 5-(trifluoromethoxyl)indoline-2,3-dione 5-(trifluoromethoxy)indoline-2,3-dione 5-(trifluoromethoxy)indoline-2,3-dione97% 5-(trifluoromethoxy)isatin97% 5-(Trifluoromethoxyl)-isatin 5-(Trifluoromethoxy)-1H-indole-2,3-dione buttpark34\07-90

Molecular Formula: C9H4F3NO3

Molecular Weight: 231.13

MDL Number: MFCD00192524

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

5-(Trifluoromethoxy)-1H-indole-2,3-dione, also known as 5-trifluoromethoxyisatin, is a heterocyclic organic compound featuring an isatin core substituted with a trifluoromethoxy group at the 5-position. It is a pale yellow to yellow crystalline powder. This compound is primarily utilized as a key synthetic intermediate in medicinal chemistry. The isatin scaffold is a privileged structure in drug discovery, known for its diverse biological activities. The introduction of the trifluoromethoxy group, a common pharmacophore, enhances lipophilicity and metabolic stability. Consequently, 5-trifluoromethoxyisatin serves as a crucial building block for the synthesis of various biologically active molecules, including potential kinase inhibitors and other therapeutic agents targeting central nervous system disorders and infectious diseases. As a functionalized isatin derivative, it is a valuable reagent in organic synthesis, particularly for constructing complex heterocyclic systems via condensation, ring expansion, and multicomponent reactions.

Physical Properties

Melting Point: 170-172 °C(lit.)

Density: 1.562 g/cm3

Storage: Keep Cold