1-Methyl-3,5-bis-O-(2,4-dichlorobenzyl)-alpha-D-ribofuranoside, CAS No. 168427-35-8

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168427-35-8

Catalog No. EBD52782

CAS 168427-35-8

Name 1-Methyl-3,5-bis-O-(2,4-dichlorobenzyl)-alpha-D-ribofuranoside

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Basic Information

Synonyms: 1-Methyl-3,5-bis-(2,4-dichloro-benzyl)-Alpha-D-Ribofuranoside methyl3,5-bis-o-(2,4-dichlorobenzyl)-α-d-ribofuranoside methyl3,5-di-o-(2,4-dichlorobenzyl)-a-d-ribofuranoside 1-o-methyl3,5-bis-o-(2,4-dichlorobenzyl)-α-d-ribofuranoside methyl3,5-bis-o-[(2,4-dichlorophenyl)methyl]-α-d-ribofuranoside 1-Methyl-3,5-bis-O-(2,4-dichlorobenzyl)-alpha-D-ribofuranoside

Molecular Formula: C20H20Cl4O5

Molecular Weight: 482.18

MDL Number: MFCD00800345

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

1-Methyl-3,5-di-O-(2,4-dichlorobenzyl)-alpha-D-ribofuranose is a protected ribofuranose derivative, specifically a 1-methyl glycoside with 2,4-dichlorobenzyl (DCB) protecting groups at the 3- and 5-positions of the sugar ring. This compound serves as a crucial synthetic intermediate in nucleoside chemistry. Its primary application is in the synthesis of modified nucleosides and nucleotides, which are key building blocks for antiviral and anticancer drugs. The 2,4-dichlorobenzyl groups are robust protecting groups for the hydroxyl functions, allowing for selective manipulation at other positions of the sugar moiety during multi-step synthetic sequences aimed at producing therapeutic nucleoside analogs. This intermediate is valued for its role in constructing complex, biologically active molecules, particularly in medicinal chemistry research focused on developing new antiviral agents and exploring the structure-activity relationships of nucleoside-based pharmaceuticals.

Physical Properties

Boiling Point: 584.13 °C at 760 mmHg

Flash Point: 307.071 °C

Density: 1.5 g/cm3