4-Hydroxy-1-methyl-1H-quinolin-2-one, CAS No. 1677-46-9

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1677-46-9

Catalog No. EBD29793

CAS 1677-46-9

Name 4-Hydroxy-1-methyl-1H-quinolin-2-one

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Basic Information

Synonyms: 4-Hydroxy-1-methyl-1H-quinolin-2-one auroraka-2363 4-hydroxy-1-methyl-2-quinolone 4-hydroxy-1-methyl-1,2-dihydroquinolin-2-one 4-hydroxy-1-methyl-2(1h)-quinolone 4-hydroxy-n-methyl-2-quinolone 1-methyl-4-hydroxy-2-chinolinon 1-methyl-4-hydroxy-2-chinolon 4-hydroxy-1-methyl-2(1H)quinolone 4-Hydroxy-1-Metyl-2-(1H)Quinolone 2-hydroxy-1-methylquinolin-4(1H)-one 4-hydroxy-1-methylquinolin-2(1H)-one

Molecular Formula: C10H9NO2

Molecular Weight: 175.18

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Anti-infectives

Product Description:

4-Hydroxy-1-methyl-1H-quinolin-2-one is a heterocyclic organic compound featuring a quinolinone core structure. It serves as a key synthetic intermediate in the preparation of various biologically active molecules, particularly within the field of medicinal chemistry. Its primary industrial and research significance lies in its role as a precursor for the synthesis of quinolone and fluoroquinolone antibiotics. This compound provides the essential 4-oxo-quinoline scaffold, which is a fundamental pharmacophore in this important class of antimicrobial agents. Modifications to this core structure are crucial for developing new antibiotics with improved efficacy and spectrum of activity. Beyond its direct use in antibiotic synthesis, this compound is also investigated as a potential ligand in coordination chemistry and may find applications in the development of other therapeutic agents due to its privileged heterocyclic structure.

Physical Properties

Melting Point: 269-271 °C(lit.)

Boiling Point: 293.4°Cat760mmHg

Flash Point: 131.2°C

Density: 1.326g/cm3