1-(4-methoxyphenyl)cyclopropane-1-carboxylic acid, CAS No. 16728-01-1

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16728-01-1

Catalog No. EBD95879

CAS 16728-01-1

Name 1-(4-methoxyphenyl)cyclopropane-1-carboxylic acid

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Basic Information

Synonyms: 1-(4-methoxyphenyl)cyclopropanecarboxylicacid 1-(4-methoxyphenyl)cyclopropanecarboxylate 1-(4-methoxyphenyl)cyclopropane-1-carboxylicacid 1-(4-Methoxyphenyl)-1-cyclopropanecarboxylicacid

Molecular Formula: C11H12O3

Molecular Weight: 192.21

MDL Number: MFCD00019223

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

1-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid is a white to off-white crystalline powder. It is a cyclopropane-containing carboxylic acid derivative featuring a para-methoxyphenyl substituent. This structure makes it a versatile chiral building block in organic synthesis. This compound is primarily used as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. For instance, it is a known intermediate in the production of certain antidepressant and anxiolytic drugs, where the cyclopropane ring and the carboxylic acid functionality are essential for biological activity and metabolic stability. As a bifunctional molecule containing both a carboxylic acid and an aromatic ring, it is a valuable synthon in medicinal chemistry for constructing complex molecular architectures. It is typically handled under standard laboratory conditions, and safety data sheets should be consulted for specific handling and storage guidelines.

Physical Properties

Melting Point: 127-132 °C

Boiling Point: 347.7 °C at 760 mmHg

Flash Point: 138.6 °C

Density: 1.263 g/cm3

Solubility: Very soluble in water

Analytical Data

Appearance: White to almost white crystalline powder