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    166247-63-8

    Catalog No. EBD233918

    CAS 166247-63-8

    Name 7-deaza-2'-deoxy-7-iodoadenosine

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    Basic Information

    Synonyms: 7-deaza-2'-deoxy-7-iodoadenosine 2'-deoxy-7-iodotubercidin 4-amino-7-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine 4-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine 7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine β-D-2'-deoxy-7-iodotubercidin 7-deaza-7-iodo-2'-deoxyadenosine

    Molecular Formula: C11H13IN4O3

    Molecular Weight: 376.15

    Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    7-Deaza-2'-deoxy-7-iodoadenosine is a modified nucleoside analog characterized by a 7-deaza-7-iodo substitution on the purine base and the absence of a 2'-hydroxyl group on the ribose sugar (deoxyribose). This specific structure, featuring an iodine atom at the 7-position of the 7-deazapurine ring system, makes it a valuable synthetic intermediate and biochemical probe. Its primary application is in life science research and medicinal chemistry. The iodine atom serves as a versatile handle for further chemical modifications via cross-coupling reactions (e.g., Sonogashira, Suzuki), enabling the synthesis of a diverse array of 7-substituted-7-deaza-2'-deoxyadenosine derivatives. These derivatives are investigated for their potential as antiviral agents, particularly against DNA viruses, and as tools for studying nucleic acid interactions and enzyme mechanisms. The compound itself is also used in the synthesis of fluorescent nucleosides and other labeled analogs for diagnostic and research purposes. As a specialized, iodinated nucleoside building block, it is not a commodity chemical but a research-grade material. Handling requires standard precautions for laboratory chemicals, and it should be stored under inert atmosphere at low temperatures to maintain stability.
    Physical Properties
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