Synephrine tartrate is a salt form of synephrine, a phenethylamine alkaloid structurally similar to epinephrine and norepinephrine. It is commonly known as bitter orange extract and is the active ingredient in many dietary supplements and over-the-counter products marketed for weight loss and energy enhancement. Its primary pharmacological action is as a sympathomimetic amine, acting as an agonist on adrenergic receptors (primarily α-adrenergic). In clinical and therapeutic contexts, it is used as an active pharmaceutical ingredient (API) in decongestant medications for the relief of nasal congestion associated with colds, allergies, and sinusitis, classifying it as a respiratory system drug. Concurrently, its widespread use as a stimulant and thermogenic agent in weight management supplements places it within the realm of endocrine and metabolic drugs. While available in dietary supplements, its safety profile is a subject of ongoing discussion. It may increase blood pressure and heart rate, and interactions with other stimulants or certain medications are a concern. Regulatory status varies by region, with some countries restricting its use in food supplements due to potential cardiovascular risks.