(R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline, CAS No. 164858-78-0

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164858-78-0

Catalog No. EBD210496

CAS 164858-78-0

Name (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline

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Basic Information

Synonyms: (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline (4R)-(+)-4,5-Dihydro-2-[2'-(diphenylphosphino)phenyl]-4-isopropyloxazole Diphenylphosphinophenylmethylethyldihydrooxazole (4R)-2-[2-(diphenylphosphanyl)phenyl]-4-(1-methylethyl)-4,5-dihydro-1,3-oxazole (r)-(+)-2-[2-(diphenylphosphino)phenyl]-4-(1-isopropyl)-4,5-dihydrooxazole (r)-(+)-2-[2-(diphenylphosphino)phenyl]-4-(1-methylethyl)-4,5-dihydrooxazole (r)-(+)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-isopropyl-oxazole (4r)-(+)-4,5-dihydro-2-(2'-(diphenylphosphino)phenyl)-4-isopropyloxazole (r)-(+)-2-[2-(diphenylphosphino)phenyl]-4-(1-methylethyl)-4,5-dihydrooxazole,98% (4r)-(+)-4,5-dihydro-2-[2'-(diphenylphosphino)phenyl]-4-isopropyloxazole,98% (r)-(+)-2-[2-(diphenylphosphino

Molecular Formula: C24H24NOP

Molecular Weight: 373.43

MDL Number: MFCD02684553

Categories: Synthetic Chemistry > Catalysts and Ligands > Chiral Ligands Synthetic Chemistry > Catalysts and Ligands > Phosphorus Ligands

Product Description:

(R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline is a chiral, bidentate P,N-ligand. It features an oxazoline ring substituted with an isopropyl group at the 4-position and a diphenylphosphino group attached to the phenyl ring at the 2-position. The ligand is designed to coordinate to transition metals through both the phosphorus and nitrogen donor atoms. This compound is primarily employed as a ligand in asymmetric catalysis. Its modular structure, combining a rigid oxazoline moiety with a flexible phosphine group, allows for fine-tuning of the steric and electronic environment around the metal center. It has found significant application in various enantioselective transformations, including hydrogenation, hydroboration, and cross-coupling reactions, to produce chiral molecules with high enantiomeric excess. As a specialized chiral ligand, it is not a commodity chemical but a high-value research tool used in academic and industrial settings for the development of asymmetric synthetic methodologies. Proper handling requires standard precautions for air- and moisture-sensitive organophosphorus compounds.

Physical Properties

Melting Point: 85-90 °C

Boiling Point: 492.7 °C at 760 mmHg

Flash Point: 251.8 °C

Analytical Data

Appearance: White crystalline powder