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    163485-86-7

    Catalog No. EBD3089

    CAS 163485-86-7

    Name 8-Bromo-2-chloroquinoline

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    Basic Information

    Synonyms: 8-Bromo-2-chloroquinoline

    Molecular Formula: C9H5BrClN

    Molecular Weight: 242.5

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    8-Bromo-2-chloroquinoline is a halogenated quinoline derivative. It serves as a versatile and valuable heterocyclic building block in organic synthesis, particularly in medicinal chemistry. The presence of both bromine and chlorine atoms at the 8- and 2-positions, respectively, provides distinct reactive sites for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) or nucleophilic aromatic substitution. Its primary application is as a key synthetic intermediate in the development of pharmaceutical compounds. It is notably used in the synthesis of various biologically active molecules, including kinase inhibitors and other therapeutic agents targeting specific disease pathways. The quinoline scaffold is a privileged structure in drug discovery due to its diverse pharmacological properties. As a bifunctional halogenated heterocycle, it is a common starting material for constructing more complex molecular architectures. It is commercially available from suppliers specializing in fine chemicals and advanced intermediates for research and development.
    Physical Properties
    mg g kg ml l t