(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid, CAS No. 163437-14-7

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163437-14-7

Catalog No. EBD2199527

CAS 163437-14-7

Name (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid

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Basic Information

Synonyms: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoicacid n-alpha-(9-fluorenylmethoxycarbonyl)-l-methioninesulfone n-alpha-(9-fluorenylmethyloxycarbonyl)-l-methioninesulfon n-alpha-(9-fluorenylmethyloxycarbonyl)-l-methioninesulfone n-alpha-fmoc-l-methionine-sulfone fmoc-l-methionine-sulfone fmoc-l-met(o2)-oh fmoc-methionine(o2)-oh fmoc-met(o2)-oh Fmoc-L-methioninesulfone

Molecular Formula: C20H21NO6S

Molecular Weight: 403.45

MDL Number: MFCD00153361

Categories: Synthetic Chemistry > Organic Building Blocks > Special Functional Group Blocks

Product Description:

Fmoc-L-methionine sulfone is a protected amino acid derivative where the methionine side chain is oxidized to a sulfone group and the α-amino group is protected by a 9-fluorenylmethoxycarbonyl (Fmoc) group. This modification renders the sulfur atom inert to oxidation and alkylation reactions that are common with standard methionine, making it a valuable building block in solid-phase peptide synthesis (SPPS). Its primary application is in the synthesis of peptides that require methionine residues with enhanced stability. By incorporating Fmoc-L-methionine sulfone, researchers can prevent unwanted side reactions during peptide assembly and subsequent handling, which is crucial for producing peptides with high purity for pharmaceutical research and development. It is specifically used as a specialized, non-natural amino acid analog. This compound is a key reagent in the toolbox for preparing peptide-based drug candidates, diagnostics, and biochemical probes. Its use is specialized within peptide chemistry rather than as a general-purpose synthetic intermediate.

Physical Properties

Boiling Point: 709.476 °C at 760 mmHg

Flash Point: 382.877 °C

Density: 1.359 g/cm3

Storage: Store at RT.