2-[1-(Mercaptomethyl)cyclopropyl]acetic acid, CAS No. 162515-68-6

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

162515-68-6

Catalog No. EBD41330

CAS 162515-68-6

Name 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Get Quote

Basic Information

Synonyms: N-Boc-4-piperidinylpropionicacidmethylester 2-[1-(Mercaptomethyl)cyclopropyl]aceticacid 1-(mercaptomethyl)-cyclopropaneaceticacid 1-(mercaptomethyl)cyclopropylaceticacid montelukastintermdiates montelukastsodium-2-[1-(mercaptomethyl)cyclopropyl]aceticacid 1-(mercaptomethyl)cyclopropylaceticacid98+% montelukastintermediate 1-(mercaptomethyl)-cyclopropyl 1-(mercaptomethyl)cyclopropaneaceticacid 1-(Mercaptomethyl)-cyclopropylaceticacid [1-(sulfanylmethyl)cyclopropyl]aceticacid 2-[1-(Merocaptomethyl)Cyclopropyl]AceticAcid 2-(1-(Mercaptomethyl)cyclopropyl)aceticacid 1-(Mercaptomethyl)cyclopropaneaceticacid(B3) 1-(mercaptomethyl)cyclopropaneac

Molecular Formula: C6H10O2S

Molecular Weight: 146.2

MDL Number: MFCD03411600

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

1-Mercaptomethylcyclopropaneacetic acid is a specialized organic compound featuring both a carboxylic acid group and a thiol (mercapto) group attached to a cyclopropane ring. This unique bifunctional structure, containing a strained three-membered ring, makes it a valuable chiral building block in organic synthesis. Its primary and most significant application is as a key intermediate in the synthesis of pharmaceutical agents. It is notably utilized in the production of certain angiotensin II receptor antagonists (ARBs), a class of drugs used to treat hypertension and heart failure. The compound serves as a crucial precursor for introducing the characteristic acidic biphenyl-tetrazole moiety or related bioisosteres into these drug molecules. The thiol group allows for further functionalization through reactions like alkylation or conjugate addition, while the carboxylic acid can be used to form amide bonds. Due to the presence of the thiol group, it requires careful handling under inert atmosphere to prevent oxidation to disulfides.

Physical Properties

Melting Point: 42-46 °C

Boiling Point: 290.1 °C at 760 mmHg

Flash Point: >110 °C

Density: 1.229 g/cm3

Safety Information

Packing Level:

Hazard Category:

Transport Codes: 3335

Analytical Data

Appearance: off-white solid