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    1621160-31-3

    Catalog No. EBD3332856

    CAS 1621160-31-3

    Name (2R)-2-deoxy-2-fluoro-2-methyl-D-erythro-Pentofuranosyl chloride, 3,5-dibenzoate

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    Basic Information

    Molecular Formula: C20H18ClFO5

    Molecular Weight: 392.81

    Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

    Product Description:
    This compound, (2R)-2-deoxy-2-fluoro-2-methyl-D-erythro-pentofuranosyl chloride, 3,5-dibenzoate, is a chemically modified nucleoside derivative. It features a 2'-deoxy-2'-fluoro-2'-methyl ribose sugar moiety with a chlorine atom at the 1'-position and benzoate protecting groups at the 3'- and 5'-positions. The specific stereochemistry (2R,3R,4R) is crucial for its intended biological activity. Its primary application is as a key synthetic intermediate in the development of modified nucleoside analogs for antiviral and anticancer therapies. The 2'-fluoro-2'-methyl modification is a common strategy to enhance metabolic stability, improve binding affinity to target enzymes (like viral polymerases), and increase resistance to enzymatic degradation. This intermediate is specifically designed for incorporation into oligonucleotides or prodrugs, such as those being investigated for the treatment of hepatitis C virus (HCV) and other viral infections. As a protected and activated sugar building block, it is a specialized reagent used in sophisticated medicinal chemistry campaigns rather than a general-purpose synthetic block. Its handling requires standard precautions for moisture-sensitive and potentially toxic organic compounds.
    Physical Properties
    mg g kg ml l t