1-(4-Bromophenyl)-2,2,2-trifluoro-1-ethanone, CAS No. 16184-89-7

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16184-89-7

Catalog No. EBD225038

CAS 16184-89-7

Name 1-(4-Bromophenyl)-2,2,2-trifluoro-1-ethanone

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Basic Information

Synonyms: 4-bromo-alpha,alpha,alpha-trifluoro-acetophenone 4'-Bromo-2,2,2-trifluoroacetophenone ±,±,±-trifluoro-4-bromoacetophenone 4-bromo-±,±,±-trifluoroacetophenone 1-(4-Bromophenyl)-2,2,2-trifluoro-1-ethanone 4-trifluoroacetylbromobenzene 1-(4-bromophenyl)-2,2,2-trifluoroethylethanone 1-(4-bromo-phenyl)-2,2,2-trifluoro-ethanone

Molecular Formula: C8H4BrF3O

Molecular Weight: 253.02

MDL Number: MFCD00191862

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

4'-Bromo-2,2,2-trifluoroacetophenone is an organic compound with the molecular formula C8H4BrF3O. It is a solid at room temperature, characterized by the presence of both a bromine atom on the phenyl ring and a trifluoromethyl ketone functional group. This combination of halogen and electron-withdrawing substituents makes it a versatile building block. This compound is primarily used as a key intermediate in organic synthesis, particularly in the construction of more complex molecules. The bromine atom serves as a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Stille), while the trifluoroacetyl group is a reactive site for nucleophilic addition or condensation reactions. It finds application in the synthesis of various heterocyclic compounds and as a precursor for ligands and pharmaceutical intermediates.

Physical Properties

Melting Point: 26-30 °C(lit.)

Boiling Point: 95 °C/4 mmHg(lit.)

Flash Point: 96 °C

Density: 1.662 g/mL at 25 °C(lit.)

Analytical Data

Appearance: pale yellow transparent liquid