trans-Azetidine-2,4-dicarboxylic acid, CAS No. 161596-62-9

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161596-62-9

Catalog No. EBD2335956

CAS 161596-62-9

Name trans-Azetidine-2,4-dicarboxylic acid

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Basic Information

Synonyms: (2s,4s)-(-)-azetidine-2,4-dicarboxylicacid t-ada trans-2,4-azetidinedicarboxylicacid (+/-)-trans-azetidine-2,4-dicarboxylicacid (2s,4s)-(-)-azetidine-2,4-dicarboxylicacid98% 2,4-azetidinedicarboxylicacid,(2s,4s)-(9ci) trans-azetidine-2,4-dicarboxylicacidsolid TRANS-AZETIDINE-2,4-DICARBOXYLICACID (2S,4S)-azetidinium-2,4-dicarboxylate 2,4-azetidinedicarboxylicacid,(2R,4R)- 2,4-azetidinedicarboxylicacid,(2r-trans)- (2R,4R)-(+)-Azetidine-2,4-dicarboxylicacid 2,4-azetidinedicarboxylicacid,(2R,4R)-rel- 2,4-azetidinedicarboxylicacid azetidine-2,4-dicarboxylicacid

Molecular Formula: C5H7NO4

Molecular Weight: 145.11

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

Trans-Azetidine-2,4-dicarboxylic acid is a conformationally restricted, cyclic analog of the excitatory neurotransmitter L-glutamic acid. Its structure features a four-membered azetidine ring with two carboxylic acid groups in a trans configuration. This compound is a solid at room temperature. This molecule is primarily utilized as a key research tool and a specialized synthetic building block in medicinal chemistry and neuroscience. It acts as a potent and selective agonist for group II metabotropic glutamate receptors (mGluRs), specifically mGlu2 and mGlu3. Due to this pharmacological profile, it serves as a crucial chemical probe for studying the function of these receptors in the central nervous system and has been investigated in the context of developing potential therapeutics for neurological and psychiatric disorders, such as anxiety, schizophrenia, and pain. Its rigid, cyclic structure makes it a valuable intermediate for the synthesis of more complex molecules targeting glutamate receptors. Handling requires standard precautions for laboratory chemicals.

Physical Properties

Boiling Point: 352.5°Cat760mmHg

Flash Point: 167°C