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    160709-02-4

    Catalog No. EBD3324286

    CAS 160709-02-4

    Name Posaconazole 6

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    Basic Information

    Synonyms: Posaconazole6 D-threo-Pentitol,2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-

    Molecular Formula: C45H38N6O3

    Molecular Weight: 710.82

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    The compound with CAS 160709-02-4 is a key synthetic intermediate in the production of Posaconazole, a broad-spectrum triazole antifungal agent. It is specifically referred to as "Posaconazole Intermediate 6" in the literature and patent filings. Its chemical structure is a complex heterocyclic system, central to constructing the core pharmacophore of the final active pharmaceutical ingredient (API). This intermediate is exclusively used in the multi-step synthesis of Posaconazole. The synthesis involves critical transformations, such as the formation of the fused triazole ring system, which is essential for the drug's mechanism of action—inhibition of the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, thereby disrupting ergosterol biosynthesis in fungal cell membranes. The production and quality control of this intermediate are of paramount importance in the pharmaceutical manufacturing process, as its purity directly impacts the efficacy and safety profile of the final Posaconazole drug product. It is a high-value chemical used strictly in controlled industrial synthesis settings.
    Physical Properties
    mg g kg ml l t