Ethyl 2-oxo-2-phenylacetate, CAS No. 1603-79-8

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1603-79-8

Catalog No. EBD12385

CAS 1603-79-8

Name Ethyl 2-oxo-2-phenylacetate

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Basic Information

Synonyms: Ethyl2-oxo-2-phenylacetate Ethylphenylglyoxylate Benzoylformicacidethylester Ethylbenzoylformate ethyloxo(phenyl)acetate rarechemalbi0384 phenylethylglyoxylate phenylglyoxylicacidethylester alpha-oxo-benzeneaceticaciethylester benzenaceticacid,-oxoethylester benzeneaceticacid,α-oxo-,ethylester ethyloxophenylacetate

Molecular Formula: C10H10O3

Molecular Weight: 178.18

MDL Number: MFCD00009120

Categories: Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Synthetic Chemistry > Basic Synthetic Reagents > C-C Bond Formation Reagents

Product Description:

Ethyl benzoylformate is an organic compound with the molecular formula C10H10O3. It is an ester derivative of benzoylformic acid, featuring both a ketone (benzoyl) and an ester (ethoxycarbonyl) functional group on the same carbon atom. This α-ketoester structure makes it a versatile and reactive synthetic building block. Its primary application is in organic synthesis, where it serves as a key precursor for various reactions. It is notably used in the synthesis of heterocyclic compounds, such as isoquinolines and other nitrogen-containing structures. Furthermore, it acts as an effective acyl anion equivalent or a 1,2-dielectrophile in carbon-carbon bond-forming reactions, including Reformatsky-type reactions and condensations with active methylene compounds to yield α-hydroxy-β-keto esters or related derivatives. The compound is also utilized in the preparation of pharmaceutical intermediates and fine chemicals. As a reactive α-ketoester, it requires careful handling under inert conditions to prevent decomposition, and it is typically stored at low temperatures.

Physical Properties

Boiling Point: 138-139 °C/18 mmHg(lit.)

Flash Point: >113 °C

Density: 1.122 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.516(lit.)

Analytical Data

Appearance: clear colorless to greenish liquid