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    16013-85-7

    Catalog No. EBD968987

    CAS 16013-85-7

    Name 2,6-Dichloro-3-nitropyridine

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    Basic Information

    Synonyms: 2,6-二氯-3-硝基吡啶 2,6-二氯-3-硝基吡啶 3-硝基-2,6-二氯吡啶 二氯-3-硝基吡啶

    Molecular Formula: C5H2Cl2N2O2

    Molecular Weight: 192.99

    MDL Number: MFCD00006234

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    2,6-Dichloro-3-nitropyridine is a halogenated and nitrated heterocyclic compound. It serves as a versatile and valuable building block in organic synthesis, particularly in the pharmaceutical industry. The presence of two chlorine atoms at the 2- and 6-positions and a nitro group at the 3-position makes it a reactive intermediate for nucleophilic aromatic substitution and further functional group transformations. Its primary application is as a key synthetic intermediate in the preparation of various active pharmaceutical ingredients (APIs) and agrochemicals. It is notably used in the synthesis of complex molecules like the anti-inflammatory drug Tenidap and other pyridine-based derivatives with biological activity. The compound allows for the sequential introduction of different substituents, enabling the construction of diverse pharmacophores. As a solid, it requires careful handling due to its potential toxicity and irritant properties. It is typically stored under inert conditions to maintain stability. Its role is firmly established in medicinal chemistry research and development for creating novel therapeutic agents.
    Physical Properties

    Melting Point: 55-60 °C(lit.)

    Boiling Point: 295.5 °C at 760 mmHg

    Flash Point: 110 °C

    Density: 1.629 g/cm3

    Analytical Data

    Appearance: yellow crystalline powder or chunks

    mg g kg ml l t