4-(Trifluoromethyl)pyridine-3-carboxylic acid, CAS No. 158063-66-2

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

158063-66-2

Catalog No. EBD15970

CAS 158063-66-2

Name 4-(Trifluoromethyl)pyridine-3-carboxylic acid

Get Quote

Basic Information

Synonyms: 4-(Trifluoromethyl)pyridine-3-carboxylicacid buttpark4357-42 4-(trifluoromethyl)nicotinicacid rarechemalbo0760 4-(trifluoromethyl)nicotinicacid98% 4-(trifluromethyl)nicotinicacid 4-(trifluoromethyl)pyridine-3-carboxylicacid,3-carboxy-4-(trifluoromethyl)pyridine 2,6-dichloro-4-(trifluoromethyl)pyridine-3-carboxamide 4-(Trifluoromethyl)-3-pyridinecarboxylicacid 4-Trifluoromethylnicotinicacid

Molecular Formula: C7H4F3NO2

Molecular Weight: 191.11

MDL Number: MFCD00082626

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

4-(Trifluoromethyl)nicotinic acid is an organic compound featuring a pyridine ring substituted with a carboxylic acid group at the 4-position and a trifluoromethyl group. It is a white to off-white crystalline powder. The presence of both the electron-withdrawing trifluoromethyl group and the carboxylic acid functionality makes it a versatile and valuable building block in medicinal chemistry. This compound is primarily used as a key pharmaceutical intermediate. Its most notable application is in the synthesis of Aprepitant (Emend®), a neurokinin-1 (NK1) receptor antagonist used for the prevention of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). The molecule serves as a crucial precursor for constructing the core structure of the drug. Beyond this specific application, its structural motif is of interest in the development of other bioactive molecules, particularly in the areas of central nervous system (CNS) and anti-inflammatory agents. As a nicotinic acid derivative, it is a member of the heterocyclic carboxylic acid family. It requires careful handling in a well-ventilated environment, and personal protective equipment should be used to avoid inhalation or skin contact.

Physical Properties

Melting Point: 146-148 °C(lit.)

Boiling Point: 290.4 °C at 760 mmHg

Flash Point: 129.4 °C

Density: 1.484 g/cm3