2-(4-Hydroxyphenyl)acetic acid, CAS No. 156-38-7

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156-38-7

Catalog No. EBD26771

CAS 156-38-7

Name 2-(4-Hydroxyphenyl)acetic acid

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Basic Information

Synonyms: 4-Hydroxyphenylaceticacid p-Hydroxyphenylaceticacid (4-hydroxyphenyl)acetate 4-Hydroxybenzeneaceticacid (p-hydroxyphenyl)-aceticaci 4-carboxymethylphenol 4-hydroxy-benzeneaceticaci 4-hydroxyphenylethanoicacid aceticacid,(p-hydroxyphenyl)- ethanoicacid,4-hydroxyphenyl- 2-(4-Hydroxyphenyl)aceticacid

Molecular Formula: C8H8O3

Molecular Weight: 152.15

MDL Number: MFCD00004347

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

4-Hydroxyphenylacetic acid is an organic compound featuring a benzene ring substituted with a hydroxymethyl group and a carboxylic acid group at the para positions. It is a white to off-white crystalline powder with a molecular formula of C8H8O3. This compound serves as a crucial pharmaceutical intermediate. It is a key building block in the synthesis of atenolol, a widely used beta-blocker for treating cardiovascular diseases such as hypertension and angina pectoris. Its structure allows for further chemical modifications to create the core pharmacophore of the drug. Beyond its primary role in atenolol synthesis, 4-hydroxyphenylacetic acid is also utilized as a versatile synthon in organic chemistry for constructing more complex molecules. It finds applications in research related to fine chemicals and as a precursor for other bioactive compounds.

Physical Properties

Melting Point: 148-151 °C(lit.)

Boiling Point: 346.6 °C at 760 mmHg

Flash Point: 177.6 °C

Density: 1.319 g/cm3

Analytical Data

Appearance: white or light yellow crystalline powder