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    155560-04-6

    Catalog No. EBD2199027

    CAS 155560-04-6

    Name N-(3-endo)-9-Azabicyclo[3.3.1]non-3-ylcarbamic acid 1,1-dimethylethyl ester

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    Basic Information

    Molecular Formula: C13H24N2O2

    Molecular Weight: 240.34

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    N-(3-endo)-9-Azabicyclo[3.3.1]non-3-ylcarbamic acid 1,1-dimethylethyl ester is a bicyclic amine derivative featuring a 9-azabicyclo[3.3.1]nonane scaffold with a Boc-protected amino group at the endo-3 position. This compound serves as a crucial chiral building block in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of pharmaceutical compounds. The rigid, bridged bicyclic structure is a privileged scaffold found in molecules targeting the central nervous system (CNS), particularly as a component of potent and selective ligands for nicotinic acetylcholine receptors (nAChRs). It is extensively used in research and development for creating novel therapeutic agents. As a Boc-protected amine, it offers excellent stability and handling properties for subsequent synthetic manipulations, such as peptide coupling or deprotection to generate a free amine for further functionalization. Its defined stereochemistry (endo) is critical for achieving desired biological activity in the final drug candidates.
    Physical Properties
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