3-(1-benzothien-3-yl)-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-alanine, CAS No. 154902-51-9

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154902-51-9

Catalog No. EBD801088

CAS 154902-51-9

Name 3-(1-benzothien-3-yl)-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-alanine

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Basic Information

Synonyms: 3-(1-benzothien-3-yl)-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-alanine N-Boc-L-3-benzothienylalanine N-tert-butoxycarbonyl-L-3-(3-benzothienyl)alanine BOC-L-3-BENZOTHIENYLALANINE RARECHEMBKPT0204 N-ALPHA-T-BOC-BETA-(3-BENZOTHIENYL)-L-ALANINE N-ALPHA-T-BUTOXYCARBONYL-3-(3-BENZOTHIENYL)-L-ALANINE BOC-3-(3-BENZOTHIENYL)-L-ALANINE BOC-L-3-BENZOTHIENYLALA BOC-L-3-(3-BENZOTHIENYL)ALANINE BOC-BTA-OH 3-(1-benzothiophen-3-yl)-N-(tert-butoxycarbonyl)-L-alanine ?Boc-L-3-Benzothienylalanine

Molecular Formula: C16H19NO4S

Molecular Weight: 321.39

MDL Number: MFCD00237538

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

N-Boc-L-3-benzothienylalanine is a non-natural, protected amino acid derivative. Its structure features an L-configuration alanine backbone where the side chain is substituted with a benzothiophene moiety, and the alpha-amino group is protected by a tert-butoxycarbonyl (Boc) group. This combination of a heterocyclic aromatic system and a protected amino acid functionality makes it a specialized building block. This compound is primarily used in peptide chemistry and medicinal chemistry research as a key intermediate. The benzothiophene group is a privileged scaffold in drug discovery, often contributing to binding affinity and metabolic stability. Therefore, N-Boc-L-3-benzothienylalanine is employed in the solid-phase or solution-phase synthesis of novel peptides and peptidomimetics designed for probing biological targets or developing potential therapeutic agents, particularly in areas like oncology and central nervous system disorders. As a Boc-protected derivative, it allows for selective deprotection under mild acidic conditions, facilitating sequential peptide chain elongation. It is handled as a fine chemical for research purposes under standard laboratory safety protocols.

Physical Properties

Boiling Point: 514.1 °C at 760 mmHg

Flash Point: 264.7 °C

Density: 1.274 g/cm3

Storage: -15°C