3-Bromopropionyl chloride, CAS No. 15486-96-1

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15486-96-1

Catalog No. EBD706

CAS 15486-96-1

Name 3-Bromopropionyl chloride

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Basic Information

Synonyms: Propanoylchloride,3-bromo- 3-bromopropanoylchloride 2-(4-Methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethan-1-one 2(4'-Methoxyphenyl)-2',4',6'-trihydroxyacetophenone 3-Bromopropionylchloride 3-bromo-propanoylchlorid b-bromopropanoylchloride b-bromopropionylchloride 3-bromopropanoicacidchloride 3-bromopropionicacidchloride 3-bromopropionylchloride,tech.

Molecular Formula: C3H4BrClO

Molecular Weight: 171.42

MDL Number: MFCD00000746

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Basic Synthetic Reagents > Halogenation Reagents

Product Description:

3-Bromopropionyl chloride is a versatile bifunctional organic reagent characterized by a reactive acid chloride group and a terminal bromine atom. This colorless to pale yellow liquid is a highly reactive acylating and alkylating agent, widely used in organic synthesis. Its primary application is as a key building block in the synthesis of various heterocyclic compounds, pharmaceuticals, and functional materials. The acid chloride moiety readily undergoes reactions with nucleophiles such as amines and alcohols to form amides or esters, while the bromine atom can participate in further substitution or coupling reactions (e.g., nucleophilic substitution, Heck reaction). This makes it a valuable precursor for introducing the 3-bromopropionyl group into target molecules. Due to its high reactivity, it must be handled with care under inert atmosphere and anhydrous conditions. It is moisture-sensitive and reacts violently with water, alcohols, and amines, releasing hydrogen chloride gas. It is commonly used in the synthesis of enzyme inhibitors, polymer precursors, and other fine chemicals.

Physical Properties

Boiling Point: 55-57 °C/17 mmHg(lit.)

Flash Point: 79 °C

Density: 1.701 g/mL at 25 °C(lit.)

Solubility: REACTS

Refractivity: n20/D 1.49(lit.)

Storage: 2-8°C

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3265

Analytical Data

Appearance: clear yellow liquid