1,5-ANHYDRO-D-GLUCITOL, CAS No. 154-58-5

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154-58-5

Catalog No. EBD3059557

CAS 154-58-5

Name 1,5-ANHYDRO-D-GLUCITOL

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Basic Information

Synonyms: (2r,3r,4r,5s)-2-(hydroxymethyl)oxane-3,4,5-triol 1,5-anhydro-d-sorbitolcrystalline ACERITOL POLYGALITOL 1-DEOXYGLUCOSE 1-DEOXY-D-GLUCOSE 1,5-ANHYDROSORBITOL 1,5-ANHYDRO-D-SORBITOL 1,5-ANHYDRO-D-GLUCITOL 1-DEOXY-D-GLUCOPYRANOSE D-GLUCITOL,1,5-ANHYDRO- 1,5-anhydrohexitol

Molecular Formula: C6H12O5

Molecular Weight: 164.16

Categories: Medicinal Chemistry > Pharmaceutical Excipients > Pharmaceutical Sweeteners Functional Chemicals > Food Additives and Ingredients > Food Sweeteners

Product Description:

1,5-Anhydro-D-glucitol, also known as 1,5-anhydroglucitol or 1,5-AG, is a polyol derivative of glucose. It is a naturally occurring monosaccharide derivative found in the human body and various foods. Structurally, it is a 1-deoxy form of glucose, where the anomeric hydroxyl group is replaced by a hydrogen atom. Its primary industrial and commercial application is as a low-calorie, non-cariogenic (non-cariogenic) sweetener and bulking agent. It exhibits about 60-70% of the sweetness of sucrose and has a clean, sugar-like taste with minimal aftertaste. Due to its high stability, low hygroscopicity, and good solubility, it is used in the formulation of sugar-free and reduced-calorie food products, chewing gums, candies, and pharmaceuticals. In the medical field, it serves as a functional excipient, particularly in chewable tablets and oral care products, leveraging its sweetening and texturizing properties. Notably, in clinical diagnostics, serum 1,5-AG levels are a well-established short-term marker for monitoring glycemic control, specifically postprandial hyperglycemia, in patients with diabetes. This application is distinct from its use as a bulk sweetener.

Physical Properties

Melting Point: 142-143 °C

Boiling Point: 376.8 °C at 760 mmHg

Flash Point: 181.7 °C

Density: 1.533 g/cm3

Analytical Data

Appearance: White crystals