ginkgolide B, CAS No. 15291-77-7

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15291-77-7

Catalog No. EBD952954

CAS 15291-77-7

Name ginkgolide B

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Basic Information

Synonyms: 3-terc-butylhexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b][3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione 6H-9,4a-(epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione,11-(1,1-dimethylethyl)hexahydro-1,4b,8-trihydroxy-5-methyl-,(1R,3aR,4aR,4bR,5S,7aS,8S,9R,11S)-

Molecular Formula: C20H24O10

Molecular Weight: 424.4

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products

Product Description:

Ginkgolide B is a diterpene lactone and a major bioactive constituent isolated from the leaves of Ginkgo biloba. It possesses a unique cage-like molecular structure consisting of six five-membered rings and multiple hydroxyl groups, which contributes to its potent biological activity. Ginkgolide B is primarily recognized as a potent and selective antagonist of the platelet-activating factor (PAF) receptor. This mechanism underlies its significant anti-inflammatory, anti-allergic, and neuroprotective effects. In pharmaceutical research, it is extensively studied for its potential in treating cerebral ischemia, stroke, and various neurodegenerative disorders, including Alzheimerбпs and Parkinsonбпs diseases. It is also a key component in standardized Ginkgo biloba extracts used for cognitive enhancement and vascular health. As a natural product, ginkgolide B serves as a critical lead compound for drug discovery and a standard reference for quality control of Ginkgo-based supplements. Its complex structure also makes it a challenging target for total synthesis studies in organic chemistry.

Physical Properties

Melting Point: 280°C (dec.)

Boiling Point: 762.416 °C at 760 mmHg

Flash Point: 274.337 °C

Density: 1.645 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white crystal powder